Pulmonary vasodilators may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease (PVOD). Since there are no clinical data on administration of sildenafil to patients with veno-occlusive disease, administration of sildenafil to such patients is hamiş recommended.
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The incidence of epistaxis was also higher in sildenafil -treated patients with a concomitant oral vitamin K antagonist (9% versus 2% in those derece treated with concomitant vitamin K antagonist).
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In cases of overdose, standard supportive measures should be adopted bey required. Renal dialysis is derece expected to accelerate clearance kakım sildenafil is highly bound to plasma proteins and it is derece eliminated in the urine.
Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood .
Oprez! Upotreba Cobra Tablete 120 se ne preporučuje osobama sa srčanim problemima, osobama sa niskim ili visokim krvnim pritiskom, oboljenjima bubrega ili jetre, osobama koje boluju od hemofilije, osobama koje pate od nekog oblika stomačnog čira, kao ni İnternet sitesi osobama sa naslednim oboljenjem očiju: retinitis pigmentose.
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Clinical studies of sildenafil did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. Other reported clinical experience katışıksız hamiş identified differences in responses between the elderly and younger patients.
Remember that this medication saf been prescribed because your doctor has judged that the benefit to you is greater than the riziko of side effects. Many people using this medication do not have serious side effects.
Caution should ultimately be exercised when sildenafil is administered to nursing women birli it is not known if sildenafil or its metabolites are excreted in human breast milk .
The safety and efficacy of sildenafil indicated for treating PAH in a woman during labor and delivery have hamiş been studied .
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